14.13 Red cell folate (categories 2)
Over detection limit (360 to 1789 vs >=1790).
14.13.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 319.650574 | 1 | <0.0001 | *** |
| rcfolate_gp2 | 4.746904 | 1 | 0.03 | * |
| GA_samp | 87.644077 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 33.315880 | 1 | <0.0001 | *** |
| rcfolate_gp2 | 0.006379 | 1 | 0.9 | ns |
| GA_samp | 1643.003376 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 566.462807 | 1 | <0.0001 | *** |
| rcfolate_gp2 | 1.024646 | 1 | 0.3 | ns |
| GA_samp | 761.783353 | 1 | <0.0001 | *** |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp2 | 1 | Inf | 9.377 | 9.377 | 0.002 | ** |
| GA_samp | 1 | Inf | 2.058 | 2.058 | 0.2 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp2 | 1 | Inf | 9.466 | 9.466 | 0.002 | ** |
| GA_samp | 1 | Inf | 1.518 | 1.518 | 0.2 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp2 | 1 | Inf | 3.433 | 3.433 | 0.06 | ns |
| GA_samp | 1 | Inf | 1.092 | 1.092 | 0.3 | ns |
14.13.2 Model summary
Ratio of Geometric means (95% CI)
| Var | Effect | P |
|---|---|---|
| (Intercept) | 18.54 (13.47, 25.53) | <0.0001 |
| rcfolate_gp2≥1790 | 1.11 (1.01, 1.21) | 0.03 |
| GA_samp | 1.13 (1.10, 1.16) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.69 (1.42, 2.03) | <0.0001 |
| rcfolate_gp2≥1790 | 1.00 (0.95, 1.06) | 0.94 |
| GA_samp | 1.36 (1.34, 1.38) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.06 (0.05, 0.07) | <0.0001 |
| rcfolate_gp2≥1790 | 0.96 (0.90, 1.04) | 0.31 |
| GA_samp | 1.33 (1.30, 1.35) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 8.36 (5.71, 12.23) | <0.0001 |
| rcfolate_gp2≥1790 | 1.22 (1.07, 1.39) | 0.002 |
| GA_samp | 1.02 (0.99, 1.06) | 0.15 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.80 (1.21, 2.70) | 0.004 |
| rcfolate_gp2≥1790 | 1.23 (1.08, 1.41) | 0.002 |
| GA_samp | 1.02 (0.99, 1.06) | 0.22 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 4.89 (4.57, 5.23) | <0.0001 |
| rcfolate_gp2≥1790 | 1.03 (1.00, 1.06) | 0.06 |
| GA_samp | 1.00 (0.99, 1.00) | 0.30 |
14.13.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
14.13.4 Estimated marginal means
| Outcome | rcfolate_gp2 | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| PRL (ng/ml) | 360 to 1789 | 73.814 | 5.389 | 62.700 | 63.793 | 85.408 |
| PRL (ng/ml) | ≥1790 | 81.617 | 6.521 | 89.457 | 69.638 | 95.657 |
| hPL (μg/ml) | 360 to 1789 | 58.345 | 1.744 | 55.327 | 54.953 | 61.946 |
| hPL (μg/ml) | ≥1790 | 58.472 | 2.082 | 109.207 | 54.489 | 62.747 |
| GH2 (ng/ml) | 360 to 1789 | 1.458 | 0.046 | 74.897 | 1.369 | 1.553 |
| GH2 (ng/ml) | ≥1790 | 1.405 | 0.057 | 195.500 | 1.296 | 1.523 |
| Insulin (uU/ml) | 360 to 1789 | 11.045 | 0.332 | Inf | 10.414 | 11.715 |
| Insulin (uU/ml) | ≥1790 | 13.494 | 0.780 | Inf | 12.049 | 15.113 |
| HOMA-IR | 360 to 1789 | 2.324 | 0.074 | Inf | 2.183 | 2.474 |
| HOMA-IR | ≥1790 | 2.869 | 0.173 | Inf | 2.550 | 3.228 |
| Glucose (mmol/L) | 360 to 1789 | 4.721 | 0.029 | Inf | 4.664 | 4.778 |
| Glucose (mmol/L) | ≥1790 | 4.861 | 0.070 | Inf | 4.725 | 5.001 |
14.13.6 Post-hoc comparisons
| Outcome | Contrast | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|
| PRL (ng/ml) | ≥1790 / 360 to 1789 | 1.11 (1.01, 1.21) | 0.03 |
| hPL (μg/ml) | ≥1790 / 360 to 1789 | 1.00 (0.95, 1.06) | 0.9 |
| GH2 (ng/ml) | ≥1790 / 360 to 1789 | 0.96 (0.90, 1.04) | 0.3 |
| Insulin (uU/ml) | ≥1790 / 360 to 1789 | 1.22 (1.07, 1.39) | 0.002 |
| HOMA-IR | ≥1790 / 360 to 1789 | 1.23 (1.08, 1.41) | 0.002 |
| Glucose (mmol/L) | ≥1790 / 360 to 1789 | 1.03 (1.00, 1.06) | 0.06 |